肉视频

教授

周丽婷

基本情况

姓名:

周丽婷

   

              

性别:

职称:

教授

所在部门:

劳动卫生与环境卫生

最后学历:

研究生

最高学位:

博士

电话:

85619453

Email

[email protected]

 

详细情况

所在学科专业:

劳动卫生与环境卫生学

研究方向:

环境有害因素生物效应与机制

讲授课程:

《环境卫生学》、《卫生学》、《预防医学》、《现代环境卫生学》等

教育经历:

2011/92014/6,   肉视频 , 卫生毒理学, 博士
2009/9
2011/6, 肉视频 , 劳动卫生与环境卫生学, 硕士
2004/9
2009/6, 肉视频 , 预防医学, 学士

工作经历:

2025.09至今  肉视频  肉视频  教授

2025.02至今 新疆医科大学  肉视频  副院长(中组部援疆)

2022.11至今  肉视频  肉视频  院长助理

2021.01至今  肉视频  肉视频  唐敖庆青年学者/励新优秀青年教师

2019.09—2025.09  肉视频  肉视频  副教授

2015.06—2019.09  肉视频  肉视频  讲师

2014.09—2015.06  肉视频  临床第一医学院  博士后

科研项目:

1. 国家自然科学基金,SAA-FPR2通路介导肝内巨噬细胞极化在增塑剂DEHP促进代谢相关脂肪性肝病中的作用机制(82560629),2026.01-2029.12,主持

2. 吉林省科技厅自然科学基金,基于肝脏类器官研究FPR2调控PANoptosis在增塑剂DEHP促进代谢相关脂肪性肝病中的作用机制(20240101286JC),2024.01-2026.12,主持

3. 肉视频 白求恩项目,FPR2的激活在DEHP所致系统性慢性炎症中的调控机制(2022B26),2022.07-2025.06,主持

4.吉林省卫健委公共卫生项目,空气污染对人群健康影响监测与防护,2021.01-2021.12,主持

5. 国家自然科学基金,基于基因芯片研究雌激素受体作用网络在DEHP甲状腺毒性中的作用及其机制(81972996),2020.01-2023.12,第一参与

6. 吉林省教育厅科技发展计划,Notch信号通路在增塑剂DEHP所致脂代谢紊乱中的双调控机制(JJKH20201118KJ),2020.01-2021.12,主持

7. 国家自然科学基金,大气PM2.5通过Notch信号通路调控脂质水平的机制及其在冠心病发生与进展中的作用(81803190),2019.01-2021.12·,主持

8. 横向课题,系统性慢性炎症动物模型构建及治疗靶点开发,2024.12-2027.12,主持

9. 横向课题,肝脏类器官构建,2023.12-2024.12,主持,

10.横向课题,建筑劳务人员健康状况评价分析,2022.09-2024.08,主持

教改论文:

1. 2024.10,“大健康”理念下公共卫生复合型人才培养体系改革与实践—以肉视频 为例,中华疾病控制杂志

2. 2024,以能力培养为导向的多维化环境与健康课程体系构建与实践,医学卓越研究生培养改革的研究与实践

3. 2024,立德树人为根本,育木成材润无声——“学生中心、目标导向”的环境与健康人才培养, 医学卓越研究生教育教学创新实践案例

4. 2024,公共卫生硕士研究生“突发公共卫生事件应急处理”课程改革与实践,医学卓越研究生培养改革的研究与实践

科研论文:

(1) Wu, H.-D.; Yang, L.-W.; Deng, D.-Y.; Jiang, R.-N.; Song, Z.-K.; Zhou, L*.-T. The Effects of Brominated Flame Retardants (BFRs) on pro-Atherosclerosis Mechanisms. Ecotoxicol. Environ. Saf. 2023, 262, 115325. //doi.org/10.1016/j.ecoenv.2023.115325.

(2) Wang, T.; Zhao, C.; Fang, X.; Zhao, J.; Chao, W.; Bo, Y.; Zhou, L*. Healthful Plant-Based Dietary Patterns Associated with Reduced Adverse Effects of Air Pollution on COPD: Findings from a Large Cohort Study. Nutrients 2025, 17 (6), 1055. //doi.org/10.3390/nu17061055.

(3) Yang, L.; Zhang, Y.; Qi, W.; Zhao, T.; Zhang, L.; Zhou, L*.; Ye, L. Adverse Effects of PM2.5 on Cardiovascular Diseases. Rev. Environ. Health 2022, 37 (1), 71–80. //doi.org/10.1515/reveh-2020-0155.

(4) Zhou, L.; Zheng, D.; Song, X.; Zhu, J.; Qi, W.; Ding, S.; Zhang, Y.; Xu, Q.; Han, X.; Zhao, Y.; Zhao, T.; Guo, S.; Shi, Y.; Yang, L.; Ye, L. Alternated mRNA Expression of the Genes in Chromosome 9p21 Is Associated with Coronary Heart Disease and Genetic Variants in Chromosome 9p21. Thromb. Res. 2019, 178, 17–19. //doi.org/10.1016/j.thromres.2019.03.020.

(5) Zhou, L.; Zhu, Y.; Zhang, T.; Zhang, R.; Liu, Y.; Li, X.; Zhao, W.; Ye, J.; Ju, Y.; Ye, L. ANRIL Regulating the Secretion of Muc5ac Induced by Atmospheric PM2.5 via NF-κB Pathway in Beas-2B Cells. Environ. Toxicol. 2023, 38 (9), 2256–2270. //doi.org/10.1002/tox.23865.

(6) Ri, H.; Zhu, Y.; Jo, H.; Miao, X.; Ri, U.; Yin, J.; Zhou, L*.; Ye, L. Di-(2-Ethylhexyl) Phthalate and Its Metabolites Research Trend: A Bibliometric Analysis. Environ. Sci. Pollut. Res. Int. 2024, 31 (38), 50142–50165. //doi.org/10.1007/s11356-024-34533-x.

(7) Xu, Q.; Qi, W.; Zhang, Y.; Wang, Q.; Ding, S.; Han, X.; Zhao, Y.; Song, X.; Zhao, T.; Zhou, L*.; Ye, L. DNA Methylation of JAK3/STAT5/PPARγ Regulated the Changes of Lipid Levels Induced by Di (2-Ethylhexyl) Phthalate and High-Fat Diet in Adolescent Rats. Environ. Sci. Pollut. Res. Int. 2020, 27 (24), 30232–30242. //doi.org/10.1007/s11356-020-08976-x.

(8) Huo, C.; Song, Z.; Yin, J.; Zhu, Y.; Miao, X.; Qian, H.; Wang, J.; Ye, L.; Zhou, L*. Effect of Acute Cold Exposure on Energy Metabolism and Activity of Brown Adipose Tissue in Humans: A Systematic Review and Meta-Analysis. Front. Physiol. 2022, 13, 917084. //doi.org/10.3389/fphys.2022.917084.

(9) Zhang, Y.; Wang, S.; Zhu, J.; Li, C.; Zhang, T.; Liu, H.; Xu, Q.; Ye, X.; Zhou, L*.; Ye, L. Effect of Atmospheric PM2.5 on Expression Levels of NF-κB Genes and Inflammatory Cytokines Regulated by NF-κB in Human Macrophage. Inflammation 2018, 41 (3), 784–794. //doi.org/10.1007/s10753-018-0732-8.

(10) Liu, Y.; Zhang, B.; Zhang, T.; Wang, H.; Peng, L.; Zhou, L*. Effect of NF-κB Signal Pathway on Mucus Secretion Induced by Atmospheric PM2.5 in Asthmatic Rats. Ecotoxicol. Environ. Saf. 2020, 190, 110094. //doi.org/10.1016/j.ecoenv.2019.110094.

(11) Qi, W.; Xu, Q.; Xu, Y.; Wang, Z.; Yang, L.; Guo, S.; Shi, Y.; Zhao, T.; Zhou, L*.; Ye, L. Effect of Notch Pathway on Lipid Accumulation Induced by Mono-2-Ethylhexyl Phthalate on 3T3-L1 Cells. Ecotoxicol. Environ. Saf. 2021, 208, 111472. //doi.org/10.1016/j.ecoenv.2020.111472.

(12) Zhao, T.; Li, X.; Ge, Z.; Shi, J.; Wang, T.; Zhang, J.; Zhang, X.; Jiang, H.; Zhou, L*.; Ye, L. Effects of miR-200b-3p and miR-424-5p Regulating Notch Signaling Pathway on Atherosclerosis Induced by PM2.5in Vitro. Toxicology 2025, 517, 154216. //doi.org/10.1016/j.tox.2025.154216.

(13) Zhang, T.; Zheng, Y.; Gao, Y.; Zhao, T.; Guo, S.; Yang, L.; Shi, Y.; Zhou, L*.; Ye, L. Exposure to PM2.5 Affects Blood Lipid Levels in Asthmatic Rats through Notch Signaling Pathway. Lipids Health Dis. 2019, 18 (1), 160. //doi.org/10.1186/s12944-019-1102-8.

(14) Zhou, L.; Zheng, D.; Wang, S.; Zhu, J.; Jia, Y.; Sun, D.; Xu, J.; Wang, Q.; Chen, H.; Xu, F.; Li, B.; Ye, L. Genetic Association of Toll-like Receptor 4 Gene and Coronary Artery Disease in a Chinese Han Population. SpringerPlus 2016, 5 (1), 1533. //doi.org/10.1186/s40064-016-3177-2.

(15) Zhou, L.; Xie, L.; Zheng, D.; Li, N.; Zhu, J.; Wang, S.; Li, B.; Ye, L. Genetic Variants of CD40 Gene Are Associated with Coronary Artery Disease and Blood Lipid Levels. BioMed Res. Int. 2016, 2016, 1693619. //doi.org/10.1155/2016/1693619.

(16) Xu, Q.; Ding, S.; Qi, W.; Zhang, X.; Zhang, M.; Xing, J.; Ju, A.; Zhou, L*.; Ye, L. JAK3/STAT5b/PPARγ Pathway Mediates the Association between Di(2-Ethylhexyl) Phthalate Exposure and Lipid Metabolic Disorder in Chinese Adolescent Students. Chem. Res. Toxicol. 2023, 36 (5), 725–733. //doi.org/10.1021/acs.chemrestox.2c00365.

(17) Zhao, T.; Qi, W.; Yang, P.; Yang, L.; Shi, Y.; Zhou, L*.; Ye, L. Mechanisms of Cardiovascular Toxicity Induced by PM2.5: A Review. Environ. Sci. Pollut. Res. Int. 2021, 28 (46), 65033–65051. //doi.org/10.1007/s11356-021-16735-9.

(18) Fang, X.; Wang, T.; Lou, S.; Qiao, Y.; Zhang, B.; Zhou, L*. Mechanisms of Di (2-Ethylhexyl) Phthalate-Induced Lipid Metabolism Disorders: A Review. J. Appl. Toxicol. JAT 2025, 45 (12), 2463–2479. //doi.org/10.1002/jat.4867.

(19) Zhang, Y.; Wang, S.; Zhao, T.; Yang, L.; Guo, S.; Shi, Y.; Zhang, X.; Zhou, L*.; Ye, L. Mono-2-Ethylhexyl Phthalate (MEHP) Promoted Lipid Accumulation via JAK2/STAT5 and Aggravated Oxidative Stress in BRL-3A Cells. Ecotoxicol. Environ. Saf. 2019, 184, 109611. //doi.org/10.1016/j.ecoenv.2019.109611.

(20) Zhou, L.; Liu, H.; Zhang, R.; Yin, J.; Huo, C.; WangMo, K.; Hua, S.; Ye, L. MUC5B Regulates the Airway Inflammation Induced by Atmospheric PM2.5 in Rats and A549 Cells. Ecotoxicol. Environ. Saf. 2021, 221, 112448. //doi.org/10.1016/j.ecoenv.2021.112448.

(21) Yin, J.; Ju, Y.; Qian, H.; Wang, J.; Miao, X.; Zhu, Y.; Zhou, L*.; Ye, L. Nanoplastics and Microplastics May Be Damaging Our Livers. Toxics 2022, 10 (10), 586. //doi.org/10.3390/toxics10100586.

(22) Zhou, L.; Liu, Y.; Chen, X.; Wang, S.; Liu, H.; Zhang, T.; Zhang, Y.; Xu, Q.; Han, X.; Zhao, Y.; Song, X.; Ye, L. Over-Expression of Nuclear Factor-κB Family Genes and Inflammatory Molecules Is Related to Chronic Obstructive Pulmonary Disease. Int. J. Chron. Obstruct. Pulmon. Dis. 2018, 13, 2131–2138. //doi.org/10.2147/COPD.S164151.

(23) Zhao, T.; Li, X.; Qian, H.; Miao, X.; Zhu, Y.; Wang, J.; Hui, J.; Zhou, L*.; Ye, L. PM2.5 Induces the Abnormal Lipid Metabolism and Leads to Atherosclerosis via Notch Signaling Pathway in Rats. Toxicology 2023, 485, 153415. //doi.org/10.1016/j.tox.2022.153415.

(24) Zhao, T.; Zhang, Y.; Li, X.; Ge, Z.; Shi, J.; Wang, T.; Zhang, J.; Zhang, X.; Jiang, H.; Zhou, L*.; Ye, L. PM2.5 Induces the Instability of Atherosclerotic Plaques by Activating the Notch Signaling Pathway In Vivo and In Vitro. Environ. Toxicol. 2025, 40 (4), 683–693. //doi.org/10.1002/tox.24461.

(25) Yang, L.; Song, Z.; Pan, Y.; Zhao, T.; Shi, Y.; Xing, J.; Ju, A.; Zhou, L*.; Ye, L. PM2.5 Promoted Lipid Accumulation in Macrophage via Inhibiting JAK2/STAT3 Signaling Pathways and Aggravating the Inflammatory Reaction. Ecotoxicol. Environ. Saf. 2021, 226, 112872. //doi.org/10.1016/j.ecoenv.2021.112872.

(26) Huo, C.; Zhu, Y.; Fang, X.; Cui, J.; Ye, H.; Zhao, H.; Ye, L.; Zhou, L*. Polystyrene Microplastics Induce Injury to the Vascular Endothelial Through NLRP3-Mediated Pyroptosis. Environ. Toxicol. 2024, 39 (11), 5086–5098. //doi.org/10.1002/tox.24387.

(27) Feng, X.; Zhang, M.; Zhao, T.; Cui, J.; Ye, H.; Zhou, C.; Ye, L.; Zhou, L*. Polystyrene Microplastics Trigger Colonic Inflammation in Rats via the TLR4/NF-κB/COX-2 Pathway and Modulation of Intestinal Microbiota. Toxicology 2025, 513, 154090. //doi.org/10.1016/j.tox.2025.154090.

(28) Guo, S.; Zhang, B.; Qi, W.; Cao, X.; Xu, Y.; Zhang, X.; Li, X.; Zhou, L*.; Ye, L. Role of Estrogen Receptor Alpha in MEHP-Induced Proliferation and Invasion of SH-SY5Y Cells. Toxicology 2021, 453, 152734. //doi.org/10.1016/j.tox.2021.152734.

(29) Feng, X.; Zhang, R.; Miao, X.; Li, X.; Cui, J.; Xu, H.; Fang, X.; Zhou, C.; Ye, L.; Zhou, L*. Role of Formyl Peptide Receptor 2 in Steatosis of L02 Cells Exposed to Mono-(2-Ethylhexyl) Phthalate. Environ. Toxicol. 2024, 39 (7), 3967–3979. //doi.org/10.1002/tox.24256.

(30) Zhang, X.; Qi, W.; Shi, Y.; Li, X.; Yin, J.; Huo, C.; Zhang, R.; Zhao, W.; Ye, J.; Zhou, L*.; Ye, L. Role of miR-145-5p/ CD40 in the Inflammation and Apoptosis of HUVECs Induced by PM2.5. Toxicology 2021, 464, 152993. //doi.org/10.1016/j.tox.2021.152993.

(31) Liu, Y.; Zhou, L*.; Wu, H.; Wang, Y.; Danzengluobu,; Zhang, B. Role of Notch Signaling Pathway in Muc5ac Secretion Induced by Atmospheric PM2.5 in Rats. Ecotoxicol. Environ. Saf. 2022, 229, 113052. //doi.org/10.1016/j.ecoenv.2021.113052.

(32) Song, Z.; Wu, H.; Fang, X.; Feng, X.; Zhou, L*. The Cardiovascular Toxicity of Polystyrene Microplastics in Rats: Based on Untargeted Metabolomics Analysis. Front. Pharmacol. 2024, 15, 1336369. //doi.org/10.3389/fphar.2024.1336369.

(33) Zhou, L.; Chen, H.; Xu, Q.; Han, X.; Zhao, Y.; Song, X.; Zhao, T.; Ye, L. The Effect of Di-2-Ethylhexyl Phthalate on Inflammation and Lipid Metabolic Disorder in Rats. Ecotoxicol. Environ. Saf. 2019, 170, 391–398. //doi.org/10.1016/j.ecoenv.2018.12.009.

(34) Liu, Y.; Zhou, T.; Sun, L.; Wang, H.; Zhou, L*. The Effect of Notch Signal Pathway on PM2.5-Induced Muc5ac in Beas-2B Cells. Ecotoxicol. Environ. Saf. 2020, 203, 110956. //doi.org/10.1016/j.ecoenv.2020.110956.

(35) Zhang, R.; Yin, J.; Huo, C.; Li, X.; Ye, J.; Zhao, W.; Zhou, L*.; Ye, L. The Relationship Between Colorectal Polyps and Serum Lipid Levels: A Systematic Review and Meta-Analysis. J. Clin. Gastroenterol. 2022, 56 (8), 654–667. //doi.org/10.1097/MCG.0000000000001678.

(36) Hui, J.; Yang, L.; Xu, H.; Zhu, Y.; Zhou, L*.; Ye, L. The Relationship between MUC5AC Levels in Lung and Asthma: A Meta-Analysis Based on Animal Experiments. J. Asthma Off. J. Assoc. Care Asthma 2025, 62 (6), 962–974. //doi.org/10.1080/02770903.2024.2449248.

(37) Wang, X.; Zou, Y.; Zhang, R.; Teng, C.; Ren, X.; Zhang, H.; Zhou, L*. The Relationship between Serum Lipid Levels and Colorectal Serrated Lesions: A Systematic Review and Meta-Analysis. Front. Physiol. 2022, 13, 984586. //doi.org/10.3389/fphys.2022.984586.

(38) Shi, Y.; Qi, W.; Xu, Q.; Wang, Z.; Cao, X.; Zhou, L*.; Ye, L. The Role of Epigenetics in the Reproductive Toxicity of Environmental Endocrine Disruptors. Environ. Mol. Mutagen. 2021, 62 (1), 78–88. //doi.org/10.1002/em.22414.

(39) Pan, Y.; Yao, L.; Huang, B.; He, Y.; Xu, C.; Yang, X.; Ma, Y.; Wang, Z.; Wang, X.; Zhu, H.; Wang, M.; Song, L.; Liu, X.; Yu, G.; Ye, L.; Zhou, L*. Time Series Analysis of the Impact of Air Pollutants on Influenza-like Illness in Changchun, China. BMC Public Health 2025, 25 (1), 1456. //doi.org/10.1186/s12889-025-22110-x.

(40) Yang, L.; Ju, A.; Huang, Y.; Jiang, H.; Ye, J.; Qi, W.; Zhou, L*. Tributyl Phosphate as a Type of Environmental Endocrine Disruptor Associated with Liver Fibrosis: Insights from NHANES and in Vitro Validation. Front. Toxicol. 2025, 7, 1623830. //doi.org/10.3389/ftox.2025.1623830.

(41) Li, X.; Zhao, T.; Ye, H.; Zhao, H.; Cui, J.; Fang, X.; Zhou, L*.; Ye, L. The Spatio-Temporal Distribution and Risk Assessment of DEHP Exposure Levels in Chinese Adults from 2000 to 2018. Hum. Ecol. Risk Assess. 2024, 30 (9–10), 872–887. //doi.org/10.1080/10807039.2024.2415956.

(42) Xu, Y.; Fang, X.; Zhao, H.; Ye, H.; Cui, J.; Zhou, L*.; Zhang, Y. Exposure Level and Risk Assessment of Atrazine in Chinese Adults Based on the Systematic Review Data and the Monte Carlo Simulation Method. Hum. Ecol. Risk Assess. 2024, 30 (3–4), 394–408. //doi.org/10.1080/10807039.2024.2348067.

(43) Han, X.; Gao, Y.; Qi, W.; Ding, S.; Zhang, Y.; Xu, Q.; Zhao, Y.; Song, X.; Zhao, T.; Zhou, L*.; Ye, L. Influencing Factors of Coexistence PreDM and PreHTN in Occupational Population of State Grid Corporation of Chinese. Arch. Environ. Occup. Health 2020, 75 (6), 365–370. //doi.org/10.1080/19338244.2019.1703623.

(44) Zhang, Y.; Wang, S.; Zhu, J.; Li, C.; Zhang, T.; Liu, H.; Xu, Q.; Ye, X.; Zhou, L*.; Ye, L. Effect of Atmospheric PM2.5 on Expression Levels of NF-κB Genes and Inflammatory Cytokines Regulated by NF-κB in Human Macrophage. Inflammation 2018, 41 (3), 784–794. //doi.org/10.1007/s10753-018-0732-8.

教学成果奖:

1. 2023.06,“全域、全面、全程、多元”的多维化环境与健康课程体系构建与实践,肉视频 教学成果奖三等奖

2. 2025.10,三维融通、四证合一、开放办学:国家战略引领边疆公共卫生人才培养模式创新实践,新疆自治区教学成果奖二等奖

科研获奖:

1.吉林省人民政府,增塑剂DEHP对糖脂代谢和雌性生殖的毒作用机制,自然科学奖三等奖,2023.12

2.吉林省人民政府,中国汉族人群冠心病遗传易感性的研究,自然科学奖三等奖,2024.11

 

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